Establishment of a collection of human pluripotent stem cell lines (iPSC) from mesenchymal stem cells (MSC) from three healthy elderly donors

The study of molecular mechanism driving osteoarticular diseases like osteoarthritis or osteoporosis is impaired by the low accessibility to mesenchymal stem cells (MSC) from healthy donors (HD) for differential multi-omics analysis. Advances in cell reprogramming have, however, provided both a new source human laboratory research and strategy erase epigenetic marks involved identity development diseases. To unravel pathological signatures on MSC at origin cellular drifts during formation bone cartilage, we previously developed iPSC donors. Here present derivation three iPSCs age matched model disease further identify (epi)genomic pathology.